The terrorist, identified as Yasser Hanoun, was on his way to commit a shooting attack.
The strike comes as Prime Minister Benjamin Netanyahu has ordered the IDF to begin preparations to enter Rafah.
The strikes come just days after alleged Israeli airstrikes targeted sites in Homs in central Syria.
Syrian air defenses shot down a number of missiles, state media said, without giving details on the targets hit.
As of Monday morning, the coalition had not issued a statement about the strikes.
The IDF targeted military headquarters, infrastructure, and outposts belonging to the terrorist group Hezbollah.
Kanaani said the US attacks were designed "to overshadow the Zionist regime's crimes in Gaza." He did not indicate if Iran would take any action in response.
Syrian state media said only material damage was caused by the airstrikes.
The brigade raided terrorist hubs in the western portion of Khan Yunis, successfully killing numerous Hamas and PIJ fighters, destroying terror infrastructure, and locating many weapons.
The terrorist group says they will continue to fight US troops in Iraq until the US leaves Iraq. “Our jihad operations against the American invaders will continue until their last soldier leaves."
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